Erik Jonsson
School of Engineering & Computer Science
The University of texas at Dallas



March 4, 2016

RICHARD MURRAY // California Institute of Technology

Feedback and Control in Biological Circuit Design

Biological systems make use of feedback in an extraordinary number of ways, on scales ranging from molecules to cells to organisms to ecosystems. This lecture will discuss the use of concepts from control and dynamical systems in the analysis and design of biological feedback circuits at the molecular level. After a brief survey of relevant concepts from synthetic biology, some recent results that combine modeling, identification, design and experimental implementation of biological feedback circuits will be presented. These results include the use of intrinsic noise for system identification in transcriptional regulatory networks, analysis of the role of multiple feedback loops in providing robust behavior (ultrasensitivity and biomodality), development of feedback circuits for rate regulation and event detection, and the use of time delay as a means of designing biomolecular feedback dynamics. Using these results as examples, some of the open problems and research challenges in the area of feedback control using biological circuits will also be discussed.


Dr. Richard M. Murray is the Thomas E. and Doris Everhart Professor of Control and Dynamical Systems and Bioengineering at California Institute of Technology (Caltech), where he helped found the Control and Dynamical Systems program in 1993. He has served Caltech as interim and Division Chair (dean) of Engineering and Applied Science Center, and as Director for Information Science and Technology (IST). In 2013, Murray was elected a member of the National Academy of Engineering.


11 a.m. in TI Auditorium (ECSS 2.102).
Refreshments at 10:45 a.m. in the lobby.

FOR MORE INFORMATION, contact Jayar Medlock at 972.883.2236 or [email protected]